The festive episode will feature Ralf Little as DI Neville Parker and action that stretches from London to Saint Marie.
The 90-minute special will feature the return of Officer Dwayne Myers, played by Danny John-Jules, and a guest appearance from Juliet Stevenson.
Danny John-Jules said: "It’s always a pleasure going back to the Caribbean. After four years away, fitting back into the fold should be seamless as I know the new lead cast members. I look forward to bringing Dwayne and this 10th anniversary special script to life."
The Christmas storyline will see Detective Sergeant Florence Cassell leave the island to spend Christmas with her family, so the team welcome Dwayne with open arms to help solve a murder case.
Executive producer Tim Key said: "We’ve been talking about a Christmas episode for years so we’re beyond excited to be finally making one and to be working with Danny again. We can’t think of a better place to spend Christmas than in Saint Marie."
Tommy Bulfin, commissioning editor for BBC Drama, said: "We are delighted Death in Paradise will be bringing the sunshine to the festive schedule."