"I have decided it is time I stopped setting my alarm for 0340 in the morning."
Louise said: "I will take so many memories with me, including reporting on the shock and anguish of the Manchester Arena bombing; starting a national conversation about Menopause; and the life-changing moment I took part in the Breakfast Christmas Cycling Challenge which inspired my ongoing passion for endurance sport, which I will continue when I leave."
BBC Breakfast editor, Richard Frediani said: "Millions of viewers have regularly woken up with Louise for 20 years and welcomed her and BBC Breakfast into their homes. We will miss her brilliant journalism, good humour and boundless energy. She has been a tremendous BBC Breakfast colleague on and off screen and will always be a friend to the team."
Louise will present her final BBC Breakfast later this year.