One-fourth of the band will participate via video link at home during this weekend's show.
In a statement posted on social media, the show said: "Jade has to self-isolate this week and will therefore be carrying out her role as Mentor on 'Little Mix The Search' from home. For this Saturday's show, Jade will participate via video link, continuing to mentor alongside Jesy, Leigh-Anne and Perrie."
This weekend will see the first studio show of the series, after last weekend's show was postponed due to a COVID-19 outbreak on set.
Little Mix The Search continues Saturday at 6:25pm on BBC One.